Selected Publications

“Insights into the mechanism of cystatin C oligomer and amyloid formation and its interaction with beta-amyloid”. T.J. Perlenfein, J.D. Mehlhoff and R.M. Murphy J. Biol. Chem. (2017)

“Cerebrospinal Fluid Proteins as Regulators of Beta-Amyloid Aggregation and Toxicity”. K.M. Pate and R.M. Murphy Israel J. Chem. (2017)

"Nanoparticle Tracking for Protein Aggregation Research". X. Lu and R.M. Murphy Meth. Mol. Biol. (in press)

“TANGO-Inspired Design of Anti-Amyloid Cyclic Peptides”. X. Lu, C.R. Brickson and R.M. Murphy ACS Chem. Neurosci. 7: 1264-1274 (2016)

“Transthyretin variants with improved inhibition of β-amyloid aggregation”. P. Mangrolia, D.T. Yang and R.M. Murphy Protein Eng. Des. Sel. 29: 209-218 (2016)

“Expression, purification, and characterization of human cystatin C monomers and oligomers”. T.J. Perlenfein and R.M. Murphy Protein Expr. Purif. 117: 35-43 (2016)

“Asparagine Repeat Peptides: Aggregation Kinetics and Comparison with Glutamine Repeats”. X. Lu and R.M. Murphy Biochemistry 54: 4784-4794 (2015)

“A Cyclic Peptide Mimic of the β-Amyloid Binding Domain on Transthyretin”. P.Y. Cho, G. Joshi, M.D. Boersma, J.A. Johnson and R.M. Murphy ACS Chem. Neurosci. 6: 778-789 (2015)

"Q&A: Repeat Containing Proteins". R.M. Murphy. Nature Struct Mol Biol 22: 943-945 (2015)

“Evaluation of Nanoparticle Tracking for Characterization of Fibrillar Protein Aggregates”. D.T. Yang, X. Lu, Y. Fan and R.M. Murphy AIChE J. 60: 1236-1244 (2014)

“Synthesis and disaggregation of asparagine repeat-containing peptides”. X. Lu and R.M. Murphy J. Pept. Sci. 20: 860-867 (2014)

“Transthyretin-derived peptides as β-amyloid inhibitors”. P.Y. Cho, G. Joshi, J.A. Johnson and R.M. Murphy ACS Chem. Neurosci. 5: 542-551 (2014)

“Kinetic analysis of aggregation data”. R.M. Murphy Methods Mol. Biol. 1017: 201-217 (2013)

“Transthyretin as both a sensor and a scavenger of β-amyloid oligomers”. D.T. Yang, G. Joshi, P.Y. Cho, J.A. Johnson and R.M. Murphy Biochemistry 52: 2849-2861 (2013)

"Analysis of Aggregation Kinetic Data". R.M. Murphy In "Tandem Repeats in Genes, Proteins and Disease Meth Mol Biol 1017 D. Hatters and A.J. Hannan, editors (2013)

"Protein Misfolding and Aggregation Research: Some Thoughts on Improving Quality and Utility". R.M. Murphy and C.J. Roberts Biotechnol Prog 29: 1109-1115 (2013)

“Identification of beta-amyloid-binding sites on transthyretin”. J. Du, P.Y. Cho, D.T. Yang and R.M. Murphy Prot. Eng. Des. Sel. 25: 337-345 (2012)

“Elongation kinetics of polyglutamine peptide fibrils: a quartz crystal microbalance with dissipation study”. R.H. Walters, K.H. Jacobson, J.A. Pederson and R.M. Murphy J. Mol. Biol. 421: 329-347 (2012)

"Insights into the Molecular Mechanism of Protein Native-Like Aggregation Upon Glycation". L.M. Olivera, R.A. Gomes, D. Yang, S.R. Dennison, C. Familia, A. Lages, A.V. Coelho, R.M. Murphy, D.A. Phoenix and A. Quintas. Biochem Biophys Acta 1834: 1010-1022 (2012)

“When More is Not Better: Expanded Polyglutamine Domains in Neurodegenerative Disease”. R. M. Murphy, R. H. Walters, M. D. Tobelmann, and J. P. Bernacki. In Prefibrillar Amyloidogenic Protein Assemblies, F. Rahimi and G. Bitan, editors. To be published by Springer Books.

"Length-Dependent Aggregation of Uninterrupted Polyalanine Peptides" J. P. Bernacki and R. M. Murphy. Biochemistry 50: 9200-9211 (2011)

"Aggregation Kinetics of Interrupted Polyglutamine Peptides" R. H. Walters and R. M. Murphy, J. Mol. Biol. 412: 505-519 (2011)

“Location Trumps Length: Polyglutamine-Mediated Changes in Folding and Aggregation of a Host Protein” M.D. Tobelmann and R. M. Murphy. Biophysical J. 100: 2773-2782 (2011)

Length-dependent Aggregation of Uninterrupted Polyalanine Peptides". R.H. Walters and R.M. Murphy Biochemistry 50: 9200-9211 (2011)

“Characterizing the Interaction of Beta-Amyloid with Transthyretin Monomers and Tetramers”. J. Du and R. M. Murphy. Biochemistry 49: 8276-8289 (2010)

“Examining Polyglutamine Peptide Length: A Connection between Collapsed Conformations and Increased Aggregation”. R. H. Walters and R. M. Murphy J. Mol. Biol. 393: 978-992 (2009). [PMC2764006]

“Differential Modification of Cys10 Alters Transthyretin’s Effect on Beta-Amyloid Aggregation and Toxicity”. L. Liu, J. Hou, J. L.Du, R. S. Chumanov, Q. G. Xu, Y. Ge, J. A. Johnson and R. M. Murphy. Prot. Eng. Des. Sel. 22: 479-488 (2009) [PMC2719498]

“Model Discrimination and Mechanistic Interpretation of Kinetic Data in Protein Aggregation Studies.” J.P. Bernacki and R.M. Murphy. Biophysical Journal 96: 2871-2887, 2009.

“A Strategy for Generating Polyglutamine 'Length Libraries' in Model Host Proteins.” M.D. Tobelmann, R.L. Kerby, and R.M. Murphy. Protein Engineering Design & Selection 21: 161-164, 2008.

“Reconsidering the Mechanism of Polyglutamine Peptide Aggregation.” C.C. Lee, R.H. Walters, and R.M. Murphy. Biochemistry 46: 12810-12820, 2007.

“Protein Misfolding and Aggregation.” R.M. Murphy and B.S. Kendrick. Biotechnology Progress 23: 548-552, 2007.

“Kinetics of Amyloid Formation and Membrane Interactions with Amyloidogenic Proteins.” R. M. Murphy. Biochimica Biophysica Acta 1768: 1923-34, 2007.

“Kinetics of Inhibition of Beta-Amyloid Aggregation by Transthyretin.” L. Liu and R.M. Murphy. Biochemistry 45: 15702-15709, 2006.

“Phage Display Affords Peptides that Modulate β-Amyloid Aggregation.” B.P. Orner, L. Liu, R.M. Murphy and L.L. Kiessling. Journal of the American Chemical Society 128: 11882-11889, 2006.

“Predicting Solvent and Aggregation Effects of Peptides Using Group Contribution Methods.” J.R. Kim, T.J. Gibson, and R.M. Murphy. Biotechnology Progress 22: 605-608, 2006.

“Inhibition of Insulin Fibrillogenesis with Targeted Peptides” T. J. Gibson and R.M. Murphy. Protein Science 15: 1133-1141, 2006.

“Laser Light Scattering as an Indispensable Tool for Probing Protein Aggregation” R.M. Murphy and C.C. Lee (book chapter for Misbehaving Proteins: Protein Misfolding and Aggregation, A.S. Tsai and R.M. Murphy, editors, 2006.

“Structural Characterization of Apomyoglogin Self-Associated Species in Aqueous Buffer and Urea Solution.” C. Chow, N. Kurt, R. M. Murphy and S. Cavagnero. Biophys. J. 90: 298-309, 2006.

“Design of Peptidyl Compounds that Affect Beta-amyloid Aggregation: Importance of Surface Tension and Context”, T.J. Gibson and R. M. Murphy. Biochemistry, 44: 8898-8907, 2005.

“Urea Modulation of β-Amyloid Fibril Growth: Experimental Studies and Kinetic Modeling”. J.R. Kim, A. Muresan, K.Y.C. Lee and R.M. Murphy. Protein Science, 13: 2888-2898, 2004.

“Templated Assembly of the pH-Sensitive Membrane-Lytic Peptide GALA”. D. H. Haas and R.M. Murphy, Journal of Peptide Research 63: 451-459, 2004.

“Mechanism of Accelerated Assembly of β-Amyloid Filaments into Fibrils by KLVFFK6” J.R. Kim and R. M. Murphy, Biophysical Journal 86: 3194-3203, 2004.

“Design of a pH-sensitive Pore-Forming Peptide with Improved Performance”, D.A. Haas and R. M. Murphy, Journal of Peptide Research, 63: 9-16, 2004.

“Targeted Control of Kinetics of Beta-Amyloid Self-Association by Surface Tension-Modifying Peptides”. J.R. Kim, T. J. Gibson, and R. M. Murphy Journal of Biological Chemistry, 278: 40730 – 40735, 2003.

“Kinetics of Adsorption of Beta-Amyloid Peptide Aβ(1-40) to Lipid Bilayers” J. Kremer and R.M. Murphy. Journal of Biochemical and Biophysical Methods, 57: 159-169, 2003.

“Peptide Aggregation in Neurodegenerative Disease” R.M. Murphy. Annual Review of Biomedical Engineering 4: 155-174, 2002.

“Affinity-Based Inhibition of β-Amyloid Toxicity”. C.W. Cairo, A. Strzelec, R.M. Murphy, and L.L. Kiessling Biochemistry 41: 8620-8629, 2002.

“A Mathematical Model of the Kinetics of β-Amyloid Fibril Growth from the Denatured State”. M.M. Pallitto and R.M. Murphy, Biophysical Journal 81: 1805-1822, 2001.

“Profile of Changes in Lipid Bilayer Structure Caused by β-Amyloid Peptide”. J.J. Kremer, D.J. Sklansky, and R.M. Murphy, Biochemistry 40: 8563-8571, 2001.

“Structure-Function Relationships for Inhibitors of β-Amyloid Toxicity Containing the Recognition Sequence KLVFF”. T. L. Lowe, A. Strzelec, L.L. Kiessling, and R.M. Murphy, Biochemistry 40: 7882-7889, 2001.

“Synthesis and Characterization of Membrane-Active GALA-OKT9 Conjugates”. J. Kuehne and R.M. Murphy, Bioconjugate Chemistry 12: 742-749, 2001.

"Correlation of β-Amyloid Aggregate Size and Hydrophobicity with Decreased Bilayer Fluidity of Model Membranes". J.J. Kremer, M.M. Pallitto, D.J. Sklansky, and R.M. Murphy, Biochemistry 39: 10309-10318, 2000.

"Probing the Kinetics of Amyloid Self-Association". R.M. Murphy and M.M. Pallitto, Journal of Structural Biology 130: 109-122, 2000.

"Recognition Sequence Design of Peptidyl Modulators of β-Amyloid Aggregation and Toxicity". M. Pallitto, J. Ghanta, P. Heinzelman, L.L Kiessling and R.M. Murphy, Biochemistry 38: 3570-3578, 1999.

"Kinetics of Cellular Trafficking and Cytotoxicity of 9.2.27-Gelonin Immunotoxins Targeted Against the High Molecular Weight-Melanoma Associated Antigen". M.C. Chan and R. M. Murphy, Cancer Immunology Immunotherapy 47: 321-329, 1999.

"Coupled Cellular Trafficking and Diffusional Limitations in Delivery of Immunotoxins to Multicell Tumor Spheroids". L.A. Wenning and R.M. Murphy, Biotechnology and Bioengineering 62: 562-575, 1999.

"Quantitative Analysis of Protein Synthesis Inhibition and Recovery for CRM107 Immunotoxins". L.A. Wenning, P.T. Yazdi and R.M. Murphy, Biotechnology and Bioengineering 57: 484-496, 1998.

"Static and Dynamic Light Scattering of Biomacromolecules: What Can We Learn?". R.M. Murphy, Current Opinion in Biotechnology 8: 25-30, 1997.

"A Strategy for Design of Inhibitors of β-Amyloid Toxicity". J. Ghanta, C.-L. Shen, L.L. Kiessling and R.M. Murphy, Journal of Biological Chemistry 271: 29525-29528, 1996.

"Effect of β-Amyloid Block of the Fast Inactivating K+ Channel on Intracellular Ca2+ and Excitability in a Modelled Neuron". T.A. Good and R.M. Murphy, Proceedings of the National Academy of Science USA 93: 15130-15135, 1996.

"β-Amyloid Peptide Blocks Fast-Inactivating K+ Channels in Rat Hippocampal Neurons". T.A. Good, D. O. Smith, and R. M. Murphy, Biophysical Journal 70: 296-304, 1996.

"Influence of Cellular Trafficking on Protein Synthesis Inhibition of Immunotoxins Directed Against the Transferrin Receptor", P.T. Yazdi, L.A. Wenning, and R.M. Murphy, Cancer Research 55: 3763-3771, 1995.

"Solvent Effects on Self-Assembly of β-Amyloid Peptide". C.-L. Shen and R.M. Murphy, Biophysical Journal 69: 640-651, 1995.

"Aggregation-State Dependent Binding of β-Amyloid Peptide to Protein and Lipid Components of Rat Cortical Homogenates". T.A. Good and R.M. Murphy, Biochemical and Biophysical Research Communications 207: 209-215, 1995.

"Quantitative Analysis of Protein Synthesis Inhibition by Transferrin-Toxin Conjugates". P.T. Yazdi and R.M. Murphy, Cancer Research 54: 6387-6394, 1994.

"Effect of Acid Predissolution on Fibril Size and Fibril Flexibility of Synthetic β-Amyloid Peptide". C.-L. Shen, M.C. Fitzgerald, and R.M. Murphy, Biophysical Journal 67: 1238-1246, 1994.

"Light Scattering Analysis of Fibril Growth from the N-terminal Fragment b(1-28) of β-amyloid Peptide". C.-L. Shen, G.L. Scott, F. Merchant and R.M. Murphy, Biophysical Journal 65: 2383-2395, 1993.

"Kinetics of Aggregation of Synthetic β-Amyloid Peptide". S.J. Tomski and R.M. Murphy, Archives of Biochemistry and Biophysics 294: 630-638, 1992.

"Determining Molecular Weight Distributions of Antigen-Antibody Complexes by Quasi-Elastic Light Scattering." R.M. Murphy, M.L. Yarmush and C.K. Colton, Biopolymers 31: 1289-1295, 1991.

"Size and Structure of Antigen-Antibody Complexes: Thermodynamic Parameters." R.M. Murphy, R.A. Chamberlin, P. Schurtenberger, C.K. Colton and M.L. Yarmush, Biochemistry 29: 10889-10899, 1990.

"Staphylococcal Protein A in Neoplastic Disease: Analysis of Physicochemical Aspects." R.M. Murphy, C.K. Colton and M.L. Yarmush, Molecular Biotherapy 1: 186-207, 1989.

"Size and Structure of Antigen-Antibody Complexes: Electron Microscopy and Light Scattering Studies." R.M. Murphy, H. Slayter, P. Schurtenberger, R.A. Chamberlin, C.K. Colton and M.L. Yarmush, Biophysical Journal 454: 45-56, 1988.

"Quasi-Elastic Light Scattering of Antigen-Antibody Complexes." D.M. Yarmush, R.M. Murphy, C.K. Colton, M. Fisch and M.L. Yarmush, Molecular Immunology 25: 17-32, 1988.

Books Authored

Introduction to Chemical Processes: Principles, Analysis, Synthesis, R.M. Murphy. 2005, McGraw-Hill, Inc. 684 pp.

Books Edited

Biomaterials for Cell and Drug Delivery. MRS Symposium Proceedings, vol. 331, 1994. A.G. Mikos, R.M. Murphy, H. Bernstein and N.A. Peppas, editors. 290 pp.

Misbehaving Proteins; Protein (Mis)Folding, Aggregation, and Stability. A.S. Tsai and R.M. Murphy, editors. Springer Academic Press, New York, 2006.

Patents

"Cyclic Peptide Mimic of Beta-Amyloid Binding Domain on Transthyretin". R.M. Murphy, J.A. Johnson, P.Y. Cho, provisional patent application filed November 2014, patent application filed November 2015 (P1401391US01).

"Inhibitors of Beta-Amyloid Toxicity". L.L. Kiessling and R.M. Murphy, issued February 8, 2000 (US Patent 6,022,859).